GOLD: Geometric Optimized Latent Diffusion for RNA Structure-Aware Inverse Folding
In brief
- GOLD integrates side-chain geometry into a unified latent diffusion process for RNA design.
- It uses a GeoVAE to merge discrete sequences with continuous side-chain angles seamlessly.
- Experiments show significant gains in 3D foldability and structural validity over prior methods.
GOLD introduces a novel latent diffusion approach for RNA inverse folding that explicitly incorporates side-chain geometry. By unifying sequence and structure in a single latent space, it generates RNA sequences with improved 3D stability compared to existing methods.
What it changes for you
- HealthGOLD could speed up the design of stable 3D therapeutic molecules, reducing development costs and timelines.
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